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The purpose of the study was to examine the effect of cessation of therapeutic interventions on return of function and blood pressure. After completion of a blood volume deficit (BD) of 25%, hemorrhagic shock was maintained for 60 minutes, followed by resuscitation to a blood pressure of 70 mm Hg for 15 minutes. Hemorrhagic shock was followed by a period of observation for blood pressure and end-organ function. Hemorrhagic shock (25% BD) was induced in New Zealand white rabbits and was maintained by withdrawal of shed blood in aliquots of 20 mL every 20 minutes. After a stabilized hemorrhagic shock of 60 minutes, therapeutic intervention (resuscitation with blood and/or crystalloid and vasopressors) was started and maintained until blood pressure returned to the normal range. The animals were allowed to recover for 60 minutes. Blood pressure and cardiac output were monitored continuously. The mean arterial pressure was restored after resuscitation, but resuscitation failed to increase the cardiac output, and the ability of the kidneys to excrete sodium and water was impaired. The duration of hypotension was correlated with the duration of impaired kidney function. Hypotension, as measured by return of blood pressure, was achieved significantly earlier than renal function, which returned slowly after resuscitation. In rabbits, rapid return of blood pressure after resuscitation was associated with early restoration of renal function.: I’m curious, how did you find out about the existence of this particular
piece of armor? Or did you guys figure it out
as you continued to build the game?
MB: [laughs] It’s the classic
story of rock and roll. ‘Ah, look at that, here’s a bar with three guys
in it!’ and as soon as you walk in, you’re like ‘these dudes are weird.’ And
they are weird. [laughs] They’re like, ‘we’re not robots.’ I’m like ‘that’s
the coolest costume I’ve ever seen.’ And they’re like, ‘ ac619d1d87
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